Well, there's no antelope or mule deer in Ohio, and I don't have any plans to hunt them where they live with this setup, so those hypotheticals are really not on my radar, nor are they why I built these. If I were hunting those two animals, I'd build a flatter shooting arrow.
As for whitetails, I haven't shot a deer over 40 yards since 2007 and this arrow isn't intended to do work beyond that range. That said, I'm routinely putting 3 arrows in a softball at 50 during practice and given the right conditions, I'd take that shot on a whitetail. My bow is about as quiet as they come, so on a calm whitetail and a little ambient nature sounds, I'm not worried about the heavier arrow finding the mark. I haven't shot a deer at an unknown distance in quite a while and I practice at odd yardage, so I have a great feel for my arrow flight from 15 to 55 yards. If I booger up a shot, it's on me, not the arrow.
To your specific question, yes it's limiting, but every gear choice we make is limiting in some way, shape, or form. A 350 grain arrow with a Rage might fly flat and make you uber confident out to 60 yards, but you better hit your mark or you'll see the limitations of that particular setup.