Like any flu bug not every one will have the same reaction too it. Some people get wiped out for days on a normal run of the mill flu bug but another person shows very little symptoms of having it.
2019-nCoV (Coronavirus)
- Thread starter Jackalope
- Start date
EXCLUSIVE — A California-based biopharmaceutical company claims to have discovered an antibody that could shield the human body from the coronavirus and flush it out of a person’s system within four days, Fox News has exclusively learned.
Later Friday, Sorrento Therapeutics will announce their discovery of the STI-1499 antibody, which the San Diego company said can provide "100% inhibition" of COVID-19, adding that a treatment could be available months before a vaccine hits the market.
"We want to emphasize there is a cure. There is a solution that works 100 percent," Dr. Henry Ji, founder and CEO of Sorrento Therapeutics, told Fox News. "If we have the neutralizing antibody in your body, you don't need the social distancing. You can open up a society without fear."
CLICK HERE FOR FULL CORONAVIRUS COVERAGE
The health care and pharmaceutical industries have been scrambling to develop viable vaccines and antibody treatments as the number of COVID-19-related deaths is expected to hit 100,000 by June 1.
Many medical researchers are scrambling to find antibodies, optimistic that they could provide a remedy or preventative care in less time than it would take to develop a vaccine. Antibody treatments have been used for the past 100 years as a means to stave off infections, but their effectiveness has had mixed results. Finding a successful antibody or convalescent plasma treatment for COVID-19 could present challenges.
"Doctors are taking blood plasma from patients who have recovered from COVID-19 and infusing it into those who are critically ill. The plasma is laden with antibodies, and the approach shows some promise," former Food and Drug Administration Commissioner Scott Gottlieb wrote in a recent Wall Street Journal op-ed. "The constraint: There isn’t enough plasma from recovered patients to go around."
Some medical experts believe that while antibody research shows promise, there are concerns for how long the effects may last in fighting the virus in an infected patient.
“Antibodies, in general, have been very effective at bringing virus [levels] down if you’ve had a high burden of infection,” Phyllis Kanki, a professor of immunology and infectious diseases at the Harvard T.H. Chan School of Public Health, said in a recent interview. “There are limitations to how much you can give and for how long.”
Officials for Sorrento Therapeutics believe they have found the key to a successful treatment.
CORONAVIRUS PUTS VET'S RESPIRATORY ISSUES CAUSED BY BURN PITS TO THE TEST
Through their studies, Sorrento screened and tested billions of antibodies they have collected over the past decade. They say this made it possible to identify hundreds of potential antibody candidates that could successfully bind themselves to the spike proteins of the coronavirus. They found that a dozen of these antibodies demonstrated the ability to block the spike proteins from attaching itself to the human enzyme ACE2, which is the receptor a virus normally uses to enter human cells.
Through further testing, the researchers at Sorrento found that there was one particular antibody that showed to be 100 percent effective in blocking COVID-19 from infecting health cells — STI-1499.
"When the antibody prevents a virus from entering a human cell, the virus cannot survive," Dr. Ji said. "If they cannot get into the cell, they cannot replicate. So it means that if we prevent the virus from getting the cell, the virus eventually dies out. The body clears out that virus."
"This puts its arms around the virus. It wraps around the virus and moves them out of the body."
Dr. Ji pointed out that the antibody can be used as preventative therapy since there are no side effects, and that it can be more effective than any vaccine that may be developed.
"This is the best solution," he said. "The point of making a vaccine is to generalize a neutralizing antibody. So, if you already have one, you don't need to the body to generate one from a vaccine. You've already provided it. You're cutting out the middleman."
It was recently announced Sorrento had partnered with New York-based health care system Mount Sinai to develop an antibody cocktail. Dubbed Covi-Shield, the cocktail will be comprised of three different antibodies and, pending FDA approval, will be used as a prophylactic treatment for people returning to work and those who have been exposed to COVID-19.
POSSIBLE CORONAVIRUS VACCINE ENTERS HUMAN TESTING TRIAL
Sorrento officials said that STI-1499 will likely be the first antibody in the cocktail. They are also looking to develop the antibody as a stand-alone therapy due to its high potency, according to a statement provided to Fox News.
They said that they can provide up to 200,000 doses per month and are looking to produce tens of millions more to meet projected demands.
Mazda Releases the New 2020 CX-30Edmunds
Dr. Mark Brunswick, senior vice president of Sorrento, said that developing antibody treatments may be more effective in quickly combating the coronavirus. While a vaccine treatment can take up to 18 months, effective anti-body treatment can become available in much less time and with a much higher success rate. He points out, however, that a quick approval from the Food and Drug Administration would be needed to make the antibody treatment available within months.
CLICK HERE FOR THE FOX NEWS APP
"As soon as it is infused, that patient is now immune to the disease," Dr. Brunswick said to Fox News. "For the length of time, the antibody is in that system. So, if we were approved [by the FDA] today, everyone who gets that antibody can go back to work and have no fear of catching COVID-19."
Later Friday, Sorrento Therapeutics will announce their discovery of the STI-1499 antibody, which the San Diego company said can provide "100% inhibition" of COVID-19, adding that a treatment could be available months before a vaccine hits the market.
"We want to emphasize there is a cure. There is a solution that works 100 percent," Dr. Henry Ji, founder and CEO of Sorrento Therapeutics, told Fox News. "If we have the neutralizing antibody in your body, you don't need the social distancing. You can open up a society without fear."
CLICK HERE FOR FULL CORONAVIRUS COVERAGE
The health care and pharmaceutical industries have been scrambling to develop viable vaccines and antibody treatments as the number of COVID-19-related deaths is expected to hit 100,000 by June 1.
Many medical researchers are scrambling to find antibodies, optimistic that they could provide a remedy or preventative care in less time than it would take to develop a vaccine. Antibody treatments have been used for the past 100 years as a means to stave off infections, but their effectiveness has had mixed results. Finding a successful antibody or convalescent plasma treatment for COVID-19 could present challenges.
"Doctors are taking blood plasma from patients who have recovered from COVID-19 and infusing it into those who are critically ill. The plasma is laden with antibodies, and the approach shows some promise," former Food and Drug Administration Commissioner Scott Gottlieb wrote in a recent Wall Street Journal op-ed. "The constraint: There isn’t enough plasma from recovered patients to go around."
Some medical experts believe that while antibody research shows promise, there are concerns for how long the effects may last in fighting the virus in an infected patient.
“Antibodies, in general, have been very effective at bringing virus [levels] down if you’ve had a high burden of infection,” Phyllis Kanki, a professor of immunology and infectious diseases at the Harvard T.H. Chan School of Public Health, said in a recent interview. “There are limitations to how much you can give and for how long.”
Officials for Sorrento Therapeutics believe they have found the key to a successful treatment.
CORONAVIRUS PUTS VET'S RESPIRATORY ISSUES CAUSED BY BURN PITS TO THE TEST
Through their studies, Sorrento screened and tested billions of antibodies they have collected over the past decade. They say this made it possible to identify hundreds of potential antibody candidates that could successfully bind themselves to the spike proteins of the coronavirus. They found that a dozen of these antibodies demonstrated the ability to block the spike proteins from attaching itself to the human enzyme ACE2, which is the receptor a virus normally uses to enter human cells.
Through further testing, the researchers at Sorrento found that there was one particular antibody that showed to be 100 percent effective in blocking COVID-19 from infecting health cells — STI-1499.
"When the antibody prevents a virus from entering a human cell, the virus cannot survive," Dr. Ji said. "If they cannot get into the cell, they cannot replicate. So it means that if we prevent the virus from getting the cell, the virus eventually dies out. The body clears out that virus."
"This puts its arms around the virus. It wraps around the virus and moves them out of the body."
Dr. Ji pointed out that the antibody can be used as preventative therapy since there are no side effects, and that it can be more effective than any vaccine that may be developed.
"This is the best solution," he said. "The point of making a vaccine is to generalize a neutralizing antibody. So, if you already have one, you don't need to the body to generate one from a vaccine. You've already provided it. You're cutting out the middleman."
It was recently announced Sorrento had partnered with New York-based health care system Mount Sinai to develop an antibody cocktail. Dubbed Covi-Shield, the cocktail will be comprised of three different antibodies and, pending FDA approval, will be used as a prophylactic treatment for people returning to work and those who have been exposed to COVID-19.
POSSIBLE CORONAVIRUS VACCINE ENTERS HUMAN TESTING TRIAL
Sorrento officials said that STI-1499 will likely be the first antibody in the cocktail. They are also looking to develop the antibody as a stand-alone therapy due to its high potency, according to a statement provided to Fox News.
They said that they can provide up to 200,000 doses per month and are looking to produce tens of millions more to meet projected demands.
Mazda Releases the New 2020 CX-30Edmunds
Dr. Mark Brunswick, senior vice president of Sorrento, said that developing antibody treatments may be more effective in quickly combating the coronavirus. While a vaccine treatment can take up to 18 months, effective anti-body treatment can become available in much less time and with a much higher success rate. He points out, however, that a quick approval from the Food and Drug Administration would be needed to make the antibody treatment available within months.
CLICK HERE FOR THE FOX NEWS APP
"As soon as it is infused, that patient is now immune to the disease," Dr. Brunswick said to Fox News. "For the length of time, the antibody is in that system. So, if we were approved [by the FDA] today, everyone who gets that antibody can go back to work and have no fear of catching COVID-19."
NYC Times Square has a “Trump Death Clock” on it. Too count (as they clams) the needless deaths caused by his inaction on the covid virus.
One has too wonder if there’d of been an “Obama Death Clock” as well?
One has too wonder if there’d of been an “Obama Death Clock” as well?
My concern is that you can’t trust the people who are feeding you the information. Or the people feeding them the information. Especially when it’s in the states best interest too inflate their #’s too acquire more of the feds $$$$$$$$$$$$$$ too bolster their funds....
I hope this is true.
I don't know if this is true or bullshit - didn't see it on other networks and when Trump spoke at noon he didn't say anthing about it less i missed it - wtf
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So guys. It's not really some crazy conspiracy if you consider how a virus works. Various locations will have various transmission rates of the same virus. As mentioned earlier this is the R-value. The value is not set and varies depending on a lot of factors, most of which are not the virus itself. Let's take NY for instance. Densely populated, very small living spaces, often with shared HVAC. Nobody there has a vehicle. They either take the bus, subway, or a cab. Unlike here where we have our own car. The transportation factor alone greatly increases the R-value for them. How many people can a NY cab pick up and drop off in a day? A shit ton. Each of them exposed to either a sick driver or surface contamination. Sidewalks jammed packed with people walking cramped store isles, etc, the list goes on. Factor in that NY was probably a port of entry for the virus and had weeks longer to circulate it undetected.
So if we look at that on a time scale and let's say that the virus was introduced as a point of entry in NY on Feb 1. How long before it makes its way to say Columbus? At least a week or two before enough people are sick in NY to where one of them happens to go Columbus. So Columbus gets its first case on Feb 15. And remember it spreads way slower in Columbus than NY. Now let's say that it wasn't detected in any concerning numbers in NY until Feb 21 and people start dying on Feb 25 but it's only a small number. Then by Feb 30, it's getting worse and they close everything to stop the spread. Here's the problem. The people that you are seeing die today, were infected 3 weeks ago. What you're actually seeing on Feb 30 is the death toll from the population that got it way back on Feb 9th. In the beginning, the number of infected people is small, let's say they make up only 2% of the total infected population today on Feb 30. So even though you just locked everything down you still have a caseload of 98% that you haven't even seen yet. The same will hold true for Columbus but remember they are a couple of weeks behind and transmission was slower so far fewer people have it.
So Columbus and NY lockdown about the same time. Well, the rate of transmission may be 5x higher in NY than Columbus, plus we are two weeks behind the curve.
It's not that the virus itself is more deadly in NY than Columbus. It's that more people got infected quicker in NY so it seemed way worse and ours seemed mild.
Here is the problem with that. If we can't stop the virus then most everyone will eventually get it. An at-risk demographic is the same no matter NY or North Dakota. People with asthma in North Dakota are just as at risk of death as NY. For NY it may take 4 months for it to burn through the population and kill portions of at-risk groups. In Columbus, it may take a year due to the lower transmission rate. In Alaska, they may be dealing with this for years. In the end, however, the mortality rate will be similar across the board but vary by the number of the at-risk population in that area. In Ohio without any mitigation, it may only spread at a rate that hospitals can keep up. In NY even with mitigation, it may spread at a rate that hospitals are swamped. In North Dakota, they may have a cluster here or there for years as pockets of people are exposed due to travel. As this goes on places like NY will be the first to seem to return to normalcy, more remote populations will still have dues to pay.
So if we look at that on a time scale and let's say that the virus was introduced as a point of entry in NY on Feb 1. How long before it makes its way to say Columbus? At least a week or two before enough people are sick in NY to where one of them happens to go Columbus. So Columbus gets its first case on Feb 15. And remember it spreads way slower in Columbus than NY. Now let's say that it wasn't detected in any concerning numbers in NY until Feb 21 and people start dying on Feb 25 but it's only a small number. Then by Feb 30, it's getting worse and they close everything to stop the spread. Here's the problem. The people that you are seeing die today, were infected 3 weeks ago. What you're actually seeing on Feb 30 is the death toll from the population that got it way back on Feb 9th. In the beginning, the number of infected people is small, let's say they make up only 2% of the total infected population today on Feb 30. So even though you just locked everything down you still have a caseload of 98% that you haven't even seen yet. The same will hold true for Columbus but remember they are a couple of weeks behind and transmission was slower so far fewer people have it.
So Columbus and NY lockdown about the same time. Well, the rate of transmission may be 5x higher in NY than Columbus, plus we are two weeks behind the curve.
It's not that the virus itself is more deadly in NY than Columbus. It's that more people got infected quicker in NY so it seemed way worse and ours seemed mild.
Here is the problem with that. If we can't stop the virus then most everyone will eventually get it. An at-risk demographic is the same no matter NY or North Dakota. People with asthma in North Dakota are just as at risk of death as NY. For NY it may take 4 months for it to burn through the population and kill portions of at-risk groups. In Columbus, it may take a year due to the lower transmission rate. In Alaska, they may be dealing with this for years. In the end, however, the mortality rate will be similar across the board but vary by the number of the at-risk population in that area. In Ohio without any mitigation, it may only spread at a rate that hospitals can keep up. In NY even with mitigation, it may spread at a rate that hospitals are swamped. In North Dakota, they may have a cluster here or there for years as pockets of people are exposed due to travel. As this goes on places like NY will be the first to seem to return to normalcy, more remote populations will still have dues to pay.
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Realizing the above was clear as mud...
Red Line NY
Orange line Columbus.
Purple Lockdown
Green line on Red and Orange lines. Deaths of infected population at time of tall vertical green line.
Brown line - We are here on the timeline.
Here is what the data looks like to us today without the luxuary to see the future. It looks like NY got slammed and Ohio is doing pretty good...
But here is what the future potentially looks like. Best case. The numbers could spike.
Red Line NY
Orange line Columbus.
Purple Lockdown
Green line on Red and Orange lines. Deaths of infected population at time of tall vertical green line.
Brown line - We are here on the timeline.
Here is what the data looks like to us today without the luxuary to see the future. It looks like NY got slammed and Ohio is doing pretty good...
But here is what the future potentially looks like. Best case. The numbers could spike.
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When the Spanish flu 1918? Hit nurses took patients outside to lay in the sun not only for fresh air.
I'm pretty sure the R number doesn't change. It's just a mathematical number that describes how contagious a disease is. Part of my earlier post came from here (should have cited it at the time but forgot): https://www.healthline.com/health/r-nought-reproduction-number#covid-19-r-0
What you said about population density makes a lot of sense. They are crammed in like sardines in NY.
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Oh it changes based on a bunch of factors that influence transmission. As you know it's a measurement of the number of people a single infected person is likely to infect. In NY it could be R 9.5, and in Ohio R 2.5. That's why in your link they called it a median value.
For example. If we took 30 people and 1 infected person and placed them in a standard household bedroom for 4 hours, vs a different 30 people with one infected and placed them in a basketball stadium for the same amount of time the R-value is going to vary for both outbreaks. In the bedroom, it has the potential to be very high. In the stadium, it could be less than one. The same is true for locations. Other factors that influence it are things like I mentioned earlier. Like private vs public transportation usage, even wearing masks. The whole stay at home order was intended to lower the R-value to an acceptable level.
Ah, ok. I thought it was a fixed number but that makes sense. Thanks for the clarification.
Curious thing about those charts - it looks like the curve was already starting to trend toward leveling off even before lockdown. I would have expected to not see that start to happen till after a lockdown.
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Yeah it's not perfect. I was trying to exemplify the point that while NY got hit hard at first and we haven't, that really only means we will deal with it longer. Unless a vaccine is developed, all of the measures we are taking is only prolonging the inevitable. If we look at the old "flatten the curve" chart, the lines are the same length. One is over way before the other. Flattening the curve only prolongs the inevitable.