So I work >70 miles from home. I have a duffel in my car that has first aid kits, wool vest, blanket, lightweight sleeping bag, MRE or two, some other granola style bars, jumper cables, flares, paper maps, etc. Then I have my daily carry bag to and from work. It is a maxpedition riftcore 2.0. It can hold my p320 or p365 easily in its pistol compartment. Ialso have my tablet, laptop, cables and charging docks, extra batteries to charge my electronics in it. For BOB stuff I have an extra magazine, a quart water bottle, bushcraft style knife, electrolyte powder, along with a basic firestarting kit. Then if I feel the need Ihave an additional get home kit I've been packing in the back. Its a pelican case. In it I have an additional bushcraft style knife, tarp, wool watch cap, more complete firestarting kit, MRE, compass, folding saw, AR15 pistol along with a few magazines and ammo, life straw, gloves.
My basic idea is if I get stranded I can easily spend a semi comfortable night. If something would happen I can get myself home. If something really bad happens I can get myself home and defend myself along the way. The AR15 pistol is kept broken down and unloaded but as its a pistol it can be carried loaded with my CHL. Its also small enough that I could somewhat keep it discreet if I wanted while carrying it.