The Plaquenil melt reaction only has two raw materials, and one solvent: Dichloroquinalone, Hydroxy-novo-diamine, and Toluene. The chemistry of that reaction has remained unchanged from about 1950, until 2005. In 2005, the formulation was 'improved' (adjusted raw material ratios, to reduce side chain reactions, associated with retinal damage). It's been running that way from 2005, until now, in Rensselaer, NY. The entire supply for the US can be made in about 6 months, but the manufacturer competes with material made in India & China. If there is a 'shortage' I'd be surprised. - I rebuilt the reactor for it in 2005.