So let me get a bit academic on you here...
If you're going to define "best", or, in other words, success, you need to have a measurement. Simplified, success = dead deer. But how much more dead can you make a dead deer? Especially with an ethical, clean shot was made. Now, if you were to apply the scientific process to this conversation, you'd have an infinite number of variables to consider, making this a nearly impossible hypothesis to test, let alone reaching a definitive measurement that says "this is best for any and all combination of variables". So what I am saying is you're obsessing over a near rhetorical question. Find an informed, reasonable, acceptable solution and spend more time on shot execution than experimenting with the hypothetical.